منابع مشابه
Survival in microsatellite-unstable colorectal cancer.
To the Editors: We read with interest Malesci et al’s article in the recent issue of Clinical Cancer Research (1). They showed that microsatellite instability (MSI) was a significant stagedependent predictor of survival in patients with colorectal cancer. Malesci et al. introduced our previous results and also showed that patients with transforming growth factor-h RII– mutated MSI cancer had be...
متن کاملBackground mutation frequency in microsatellite-unstable colorectal cancer.
Microsatellite instability (MSI) is observed in approximately 12% of colorectal cancers. Genes containing a mononucleotide microsatellite in the coding sequence are particularly prone to inactivation in MSI tumorigenesis, and much work has been conducted to identify genes with high repetitive tract mutation rates in these tumors. Much less attention has been paid to background mutation frequenc...
متن کاملMolecular genetics of microsatellite-unstable colorectal cancer for pathologists
BACKGROUND Microsatellite-unstable colorectal cancers (CRC) that are due to deficient DNA mismatch repair (dMMR) represent approximately 15% of all CRCs in the United States. These microsatellite-unstable CRCs represent a heterogenous group of diseases with distinct oncogenesis pathways. There are overlapping clinicopathologic features between some of these groups, but many important difference...
متن کاملThe immune biology of microsatellite unstable cancer
Deficient DNA mismatch repair (MMR) boosts the accumulation of frameshift mutations in genes encompassing coding microsatellites (cMS). This results in the translation of proteins with mutation-induced frameshift peptides (neoantigens) rendering microsatellite-unstable (MSI) cancers highly immunogenic. MSI cancers express a defined set of neoantigens resulting from functionally relevant driver ...
متن کاملGenome-wide differences between microsatellite stable and unstable colorectal tumors.
Genomic copy number changes are frequently found in cancers and they have been demonstrated to contribute to carcinogenesis; and it is widely accepted that tumors with microsatellite instability (MSI) are genetically stable and mostly diploid. In the present study we compared the copy number alterations and the gene-expression profiles of microsatellite stable (MSS) and MSI colorectal tumors. A...
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ژورنال
عنوان ژورنال: Journal of Clinical Pathology
سال: 2001
ISSN: 0021-9746
DOI: 10.1136/jcp.54.7.573-b